Ethanol → 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt

HRID 637019노트

반응식

HRID 637019 반응식
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[N:15]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:2].[IH:22].C(O)C>C(OCC)C>[IH:22].[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[N:15]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:2]

참가 물질

5

반응물 3

HCID 702EthanolHCID 24841Hydrogen iodideHCID 9984168Emedastine EP Impurity E

생성물 1

HCID 865838874-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Combine 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (1.30 g), 48% hydriodic acid (10 mL), ethanol (10 mL), and diethyl ether (80 mL) and stir. After 30 minutes add diethyl ether, (800 mL) and continue to stir to give a solid. Collect the solid by filtration and dry in vacuo to give the title compound: mp; 156-163° C.

후처리

  1. customto give a solid
  2. customCollect the solid
  3. filtrationby filtration
  4. customdry in vacuo

출처 및 근거

ORD 기록
ord-a892962b19824ebb9f507dbad4b400bf
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194406B1

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