Methyl 5-amino-o-anisate → Methyl5-isothiocyanato-2-methoxybenzoate
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].C1C=C(O[C:21](OC2N=CC=CC=2)=[S:22])N=CC=1>ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]=[C:21]=[S:22])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]참가 물질
4
실험 절차
According to the method of Tet. Let., 26, 1661 (1985), combine methyl 2-methoxy-5-aminobenzoate (0.5 g, 2.76 mmol) and di-2-pyridyl thionocarbonate (0.64 g, 2.76 mmol) in dichloromethane (10 mL). After 30 minutes, dilute the reaction mixture with dichloromethane and extract five times with water. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give methyl 2-methoxy-5-isothiocyanatobenzoate: Rf=0.51 (silica gel, dichloromethane).
후처리
- extractionextract five times with water
- dry with materialDry the organic layer over Na2SO4
- filtrationfilter
- concentrationconcentrate in vacuo
출처 및 근거
- ORD 기록
- ord-4ac3dee6d5d94c8aa6b1ae1554ac0251
- 출처 데이터셋
- uspto-grants-2001_02
- 특허 번호
- US06194406B1
반응 노트
불러오는 중…