Dimethylformamide → 1-Methyl-4-phenoxymethyl-pyrrolidin-2-one

반응식

S([C:5]1[CH:11]=[CH:10][C:8](C)=[CH:7][CH:6]=1)([O-])(=O)=O.[O-:12][C:13]1C=CC=[CH:15][CH:14]=1.[K+].[CH3:20][N:21]([CH3:24])[CH:22]=[O:23]>>[CH3:20][N:21]1[CH2:24][CH:14]([CH2:13][O:12][C:5]2[CH:6]=[CH:7][CH:8]=[CH:10][CH:11]=2)[CH2:15][C:22]1=[O:23]

참가 물질

반응물 3

HCID 6228Dimethylformamide

HCID 85570p-Toluenesulfonate

HCID 23670670Potassium phenoxide

생성물 1

HCID 133622521-Methyl-4-phenoxymethyl-pyrrolidin-2-one

실험 절차

A solution of the resulting tosylate (21.5 g; 0.075 mole) and of potassium phenoxide (10 g; 0.075 mole) in dimethylformamide (150 ml) is refluxed for 2 hrs.

출처 및 근거

ORD 기록: ord-d84526e153214697b4cb8e1d5ae29157
출처 데이터셋: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04556674

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