Oxindole → N-cyclohexylcarbonyl-2-oxindole-1-carboxamide

HRID 637360노트

반응식

HRID 637360 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]1([C:17]([N:19]=[C:20]=[O:21])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[CH:11]1([C:17]([NH:19][C:20]([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3][C:2]2=[O:10])=[O:21])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 321710OxindoleHCID 20096062Cyclohexanecarbonyl isocyanate

생성물 1

HCID 13647650N-cyclohexylcarbonyl-2-oxindole-1-carboxamide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirred slurry of 20.0 g (0.15 mole) of 2-oxindole in 150 ml of toluene was added 29.6 g (0.19 mole) of cyclohexylcarbonyl isocyanate. The mixture was heated under reflux for ca. 30 minutes and then it was cooled to room temperature. The solid was recovered by filtration and then it was recrystallized from ethanol. This afforded 26.5 g of the title compound as fluffy, colorless crystals, m.p. 144.5°-145.5° C.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for ca. 30 minutes
  3. filtrationThe solid was recovered by filtration
  4. customit was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-893367bcce604dbfb9515c860ba36956
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556672

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