5-(4-Nitrophenyl)pyrazin-2(1H)-one → 5-(4-Aminophenyl)pyrazin-2(1H)-one

HRID 637492노트

반응식

HRID 637492 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].CN(C)C=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 138535735-(4-Nitrophenyl)pyrazin-2(1H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 123580285-(4-Aminophenyl)pyrazin-2(1H)-one수율 81.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

5-(4-Nitrophenyl)-2-(1H)-pyrazinone (0.1 g) was hydrogenated over 10% Palladium on Charcoal (0.01 g) at atmospheric pressure in 50% aqueous dimethylformamide containing 2N sodium hydroxide (0.46 ml). Once the theoretical quantity of hydrogen uptake had been observed, the reaction mixture was filtered and the filtrate treated with HCl to pH6 and evaporated. Trituration of the residue with water afforded the title compound 0.07 g, m.p. 269°-271.5° C. (with decomposition).

후처리

  1. filtrationthe reaction mixture was filtered
  2. additionthe filtrate treated with HCl to pH6
  3. customevaporated

출처 및 근거

ORD 기록
ord-e6e27ce6d2bd411cb9be712e27fbb7dc
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556711

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