2-(3-Fluoro-4-nitrophenyl)propanoic acid → 2-(4-Amino-3-fluorophenyl)propanoic acid

HRID 637611노트

반응식

HRID 637611 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:11]([CH3:15])[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>C(O)C.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH:11]([CH3:15])[C:12]([OH:14])=[O:13])=[CH:3][C:2]=1[F:1]

참가 물질

4

반응물 1

HCID 130652292-(3-Fluoro-4-nitrophenyl)propanoic acid

생성물 1

HCID 130652312-(4-Amino-3-fluorophenyl)propanoic acid수율 98.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

In 100 ml of ethanol was dissolved 3 g of 2-(3-fluoro-4-nitrophenyl)propionic acid. To the solution was added 0.25 g of 5% palladium on charcoal to conduct catalytic hydrogenation. The catalyst was filtered off and the solvent was evaporated off under reduced pressure to afford 2.55 g of 2-(4-amino-3-fluorophenyl)propionic acid as an oily substance.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated off under reduced pressure

출처 및 근거

ORD 기록
ord-d482ecece71e4affa281cdcea6661ce9
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04557871

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