Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-Thiazolecarboxamide, 2-(4-methoxyphenyl)-4-methyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Ethyl 2-chloroacetoacetate | HCID 11858 | — |
| 반응물 | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| 반응물 | 4-Methoxybenzamide | HCID 76959 | — |
| 반응물 | Ethyl 2-(4-methoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate | HCID 7540952 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Thiazolecarboxamide, 2-(4-methoxyphenyl)-4-methyl- | HCID 3068075 | 69% |
반응 단계
Into a mixed solvent of 50 ml of aqueous 28% ammonia and 450 ml of ethanol, 13.9 g of ethyl 2-(4-methoxyphenyl)-4-methylthiazole-5-carboxylate which had been prepared by heating a mixture of p-methoxybenzamide, ethyl α-chloroacetoacetate, phosphorus pentasulfide and n-butyl alcohol under a reflux for 5 hours was dissolved. Then, in a similar manner as in Example 3 the object was obtained as colourless aciculate melting at 179.5° to 180.5° C. in an amount of 8.6 g corresponding to the yield of 69%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04558059 |
| 출처 데이터셋 | uspto-grants-1985_12 |
| ORD ID | ord-09f717849cbc469691ad175eb4290b29 |
| 출처 메모 | uspto-grants-1985_12 |