Sodium Carbonate → HCID 14099940, 화합물

HRID 637816노트

반응식

HRID 637816 반응식
Cl.Cl[CH:3]([C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH2:4][NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16].C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][N:5]1[CH2:4][CH:3]1[C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 131062635-{1-Chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

생성물 1

HCID 14099940HCID 14099940, 화합물수율 88.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

In 50 ml of ethyl acetate was suspended 4.35 g (0.01 mole) of 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride and then 50 ml of an aqueous 10% sodium carbonate solution was added to the suspension with stirring. After further stirring overnight vigorously, the reaction mixture was recovered by decantation. After removing inorganic materials by passing the ethyl acetate layer thus recovered through a silica gel column (50 ml of silica gel), the reaction product was evaporated to dryness to provide 3.2 g (88%) of colorless resinous 5-{1-[2-(2-methoxyphenoxy)ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide.

후처리

  1. stirringAfter further stirring overnight vigorously
  2. customthe reaction mixture was recovered by decantation
  3. customAfter removing inorganic materials
  4. customthus recovered through a silica gel column (50 ml of silica gel)
  5. customthe reaction product was evaporated to dryness

출처 및 근거

ORD 기록
ord-70f0a2ef4b3845bcbd3794bde5e5647e
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04558156

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