Water → 4,6-Dichloro-N-(2,3-dimethylphenyl)-1,3,5-triazin-2-amine

HRID 637929노트

반응식

HRID 637929 반응식
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=1[CH3:19]>CC(C)=O>[Cl:9][C:8]1[N:1]=[C:2]([Cl:3])[N:4]=[C:5]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=2[CH3:19])[N:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 68932,3-DimethylanilineHCID 7954Cyanuric chloride

생성물 1

HCID 134137564,6-Dichloro-N-(2,3-dimethylphenyl)-1,3,5-triazin-2-amine

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
5 °C

실험 절차

A solution of cyanuryl chloride (18 g) in hot acetone (70 ml) is poured under stirring into water (40 ml). To the so obtained suspension is added, while keeping the temperature to 5° C., 2,3-xylidine (24 ml). Stirring is maintained for 1 hour at 5° C.; then the reaction mixture is filtered, the precipitate is washed with water to neutrality; it is dissolved in ethyl acetate; the solution is dried over Na2SO4. By concentration 16.8 g of the desired compound are obtained. M.p. 186°-188° C. (ethyl acetate/hexane).

후처리

  1. additionTo the so obtained suspension is added
  2. customto 5° C.
  3. filtrationthen the reaction mixture is filtered
  4. washthe precipitate is washed with water to neutrality
  5. dissolutionit is dissolved in ethyl acetate
  6. dry with materialthe solution is dried over Na2SO4

출처 및 근거

ORD 기록
ord-3b8f1c2cb536492f82ada188fe6989ca
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559345

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