Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dimethylaniline → 2-p-Methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dimethylaniline | HCID 6893 | — |
| 반응물 | 4,6-Dichloro-2[[(4-methoxyphenyl)methyl]thio]pyrimidine | HCID 13413724 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-p-Methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine | HCID 13413734 | — |
반응 단계
To a solution of 2-p-methoxybenzylthio-4,6-dichloro-pyrimidine (19.8 g) in acetonitrile (100 l) is added 2,3-xylidine (16 ml) and the resulting mixture is refluxed for 36 hours. The solid is filtered, washed with a little amount of acetonitrile, then the filtrate is concentrated to dryness. The residue is purified by chromatography on silica-gel. 17 g of the desired product are obtained. M.p. 118°-119° C. (benzene/hexane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04559345 |
| 출처 데이터셋 | uspto-grants-1985_12 |
| ORD ID | ord-d3ee6b03e19543ec810f001af24113e8 |
| 출처 메모 | uspto-grants-1985_12 |