2,3-Dimethylaniline → 6-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

HRID 637938노트

반응식

HRID 637938 반응식
[CH2:1]([S:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C([O-])([O-])=O.[Na+].[Na+].[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=1[CH3:32]>C(O)C>[CH2:1]([S:9][C:10]1[N:11]=[C:12]([Cl:17])[CH:13]=[C:14]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=2[CH3:32])[N:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 68932,3-DimethylanilineHCID 10340Sodium CarbonateHCID 134137254,6-Dichloro-2-(octylsulfanyl)pyrimidine

생성물 1

HCID 134137406-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-octylthio-4,6-dichloropyrimidine (3 g) in ethanol (25 ml), 2,3-xylidine (1,5 ml) and anhydrous Na2CO3 (1.25 g) are added; the mixture is refluxed for 20 hours. The residue is hot filtered and the solvent is evaporated. The residue is purified by chromathography on silica gel, yielding 1.9 g of 2-octylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (III, 35).

후처리

  1. temperaturethe mixture is refluxed for 20 hours
  2. filtrationThe residue is hot filtered
  3. customthe solvent is evaporated
  4. customThe residue is purified by chromathography on silica gel

출처 및 근거

ORD 기록
ord-f914c1fe74144309b8969f58fca44d9d
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559345

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