Trifluoroacetic acid → 6-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

HRID 637939노트

반응식

HRID 637939 반응식
CO[C:3]1[CH:26]=[CH:25][C:6]([CH2:7][S:8][C:9]2[N:14]=[C:13]([Cl:15])[CH:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=3[CH3:24])[N:10]=2)=[CH:5][CH:4]=1.F[C:28](F)(F)C(O)=O>>[CH2:7]([S:8][C:9]1[N:14]=[C:13]([Cl:15])[CH:12]=[C:11]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=2[CH3:24])[N:10]=1)[CH2:6][CH2:25][CH2:26][CH2:3][CH2:4][CH2:5][CH3:28]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 134137342-p-Methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine

생성물 1

HCID 134137406-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

실험 절차

To a suspension of 2-p-methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (8 g; see example 5) in trifluoroacetic acid (80 ml) anisole (2,7 ml) is added and the mixture is refluxed for 50'. After cooling, the trifluoroacetic acid is evaporated. The residue is dissolved in ethyl ether and the separated solid is filtered, washed with ethyl ether, then with water to neutrality, with cool acetone and again with ethyl ether. 5 G of the desired product (III, 33) are obtained.

후처리

  1. additionis added
  2. temperaturethe mixture is refluxed for 50'
  3. temperatureAfter cooling
  4. customthe trifluoroacetic acid is evaporated
  5. dissolutionThe residue is dissolved in ethyl ether
  6. filtrationthe separated solid is filtered
  7. washwashed with ethyl ether

출처 및 근거

ORD 기록
ord-8319fd7926ec4142b96f85f1bcc80915
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559345

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