참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Chlorobenzyl alcohol | HCID 28810 | — |
| 반응물 | Rolziracetam | HCID 71893 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 5-Oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester | HCID 15588872 | — |
반응 단계
Five grams of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione (III) are dissolved in 31 g of o-chlorobenzyl alcohol and 0.2 ml of concentrated hydrochloric acid is added. The solution is heated at 100° C. for 71 hours. The mixture is cooled and dissolved in 150 ml of anhydrous diethylether. The solution is cooled to induce crystallization and the resulting crystals are isolated by filtration. Recrystallization from toluene-diethyl ether yields 5-oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester with a melting point of 99°-100° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04559358 |
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| 출처 데이터셋 | uspto-grants-1985_12 |
|---|
| ORD ID | ord-d3fb22833c244b4f8cadb28ef832cbb2 |
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| 출처 메모 | uspto-grants-1985_12 |
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