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Dichloromethane → N-(3-(6-((dimethylamino)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)benzyl)methanesulfonamide

HRID 63800
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HRID 63800 반응식
[CH3:1][S:2](OCC1C=CC=C(C2N=C(N3CCOCC3)C3=CC(CN(C)C)=CN3N=2)C=1)(=[O:4])=[O:3].[NH2:32][CH2:33][C:34]1[CH:35]=[C:36]([C:40]2[N:45]=[C:44]([N:46]3[CH2:51][CH2:50][O:49][CH2:48][CH2:47]3)[C:43]3=[CH:52][C:53]([CH2:55][N:56]([CH3:58])[CH3:57])=[CH:54][N:42]3[N:41]=2)[CH:37]=[CH:38][CH:39]=1.ClCCl>CO>[CH3:57][N:56]([CH2:55][C:53]1[CH:52]=[C:43]2[N:42]([CH:54]=1)[N:41]=[C:40]([C:36]1[CH:35]=[C:34]([CH:39]=[CH:38][CH:37]=1)[CH2:33][NH:32][S:2]([CH3:1])(=[O:4])=[O:3])[N:45]=[C:44]2[N:46]1[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1)[CH3:58]
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참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 117988030HCID 117988030, 화합물HCID 117988239HCID 117988239, 화합물

생성물 1

HCID 72549553N-(3-(6-((dimethylamino)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)benzyl)methanesulfonamide수율 26.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Compound I-26 was prepared by the method which was identical with that for preparing compound 19, wherein compound 20 (37 mg, 0.1 mmol) was used as the starting material. Light yellow solid (12 mg, 26.7%) were obtained by a preparative plate (dichloromethane:methanol=8:1). m.p. 238-240° C. 1H NMR (300 MHz, CDCl3): δ 8.20 (s, 1H), 8.19 (d, J=7.1 Hz, 1H), 7.60 (s, 1H), 7.47-7.38 (m, 2 H), 6.88 (s, 1H), 4.41 (s, 2H), 4.02 (br, s, 4H), 3.81 (t, J=4.4 Hz, 4H), 2.95 (s, 2H), 2.94 (s, 3H), 2.87 (s, 1H), 2.51 (s, 6H). MS (EI) m/e (%): 444 (M+, 16).

후처리

  1. customCompound I-26 was prepared by the method which

출처 및 근거

ORD 기록
ord-79e071e497a8404082d038bc04e7b74b
출처 데이터셋
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09447101B2

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