Epichlorohydrin → 1,5-Dimethyl-2-[3-(2,3-epoxypropoxy)-phenyl]-pyrrole

HRID 638066노트

반응식

HRID 638066 반응식
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][CH:4]=[C:3]1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[CH:9]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:21]([CH:23]1[O:25][CH2:24]1)Cl>>[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][CH:4]=[C:3]1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:21][CH:23]2[O:25][CH2:24]2)[CH:9]=1

참가 물질

4

반응물 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 202551681,5-Dimethyl-2-(3-hydroxyphenyl)-pyrrole

생성물 1

HCID 202551361,5-Dimethyl-2-[3-(2,3-epoxypropoxy)-phenyl]-pyrrole

실험 절차

While stirring, a mixture of 10 g of the resulting crude 1,5-dimethyl-2-(3-hydroxyphenyl)-pyrrole, 50 ml of epichlorohydrin and 15.2 g of potassium carbonate is heated at boiling point for 3 hours. The reaction mixture is cooled, filtered and concentrated by evaporation. The residue is divided between 200 ml of ether and 20 ml of 2N sodium hydroxide solution; the ether phase is separated off, dried over magnesium sulphate and concentrated by evaporation. The crude 1,5-dimethyl-2-[3-(2,3-epoxypropoxy)-phenyl]-pyrrole is obtained in the form of an oil and is further used in that form.

후처리

  1. temperatureis heated
  2. customfor 3 hours
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation
  6. customthe ether phase is separated off
  7. dry with materialdried over magnesium sulphate
  8. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-1ef0c8ba247b4bc3891994ddb290965c
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559354

반응 노트

불러오는 중…