Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → m-Trifluoromethylphenylacetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 3-(Trifluoromethyl)benzyl chloride | HCID 69716 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | m-Trifluoromethylphenylacetonitrile | HCID 75360 | 107.1% |
반응 단계
A mixture of 12.0 g (61.5 mmole) m-trifluoromethylbenzyl chloride, 9.56 g (195 mmole) sodium cyanide and 60 ml dimethylsulfoxide was heated at 50° to 80° C. for four hours and poured into water. The aqueous mixture was extracted with methylene chloride, the extracts dried over sodium sulfate and the solvent evaporated in vacuo to give 12.2 g of yellow oil which was used in the next step. 1H-NMR(CDCl3)ppm(delta): 3.80 (s, 2H), 7.60 (s, 4H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04560690 |
| 출처 데이터셋 | uspto-grants-1985_12 |
| ORD ID | ord-d46f14b90c1e453ea64887a24298fe1f |
| 출처 메모 | uspto-grants-1985_12 |