3-Hydrazinopyridine → HCID 178479606, 화합물

HRID 638245

반응식

HRID 638245 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[N:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14]CC)=O.[NH:17]([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[NH2:18]>CO>[ClH:1].[N:21]1[CH:22]=[CH:23][CH:24]=[C:19]([N:17]2[C:12](=[O:14])[C:3]3=[CH:4][NH:5][C:6]4[CH:7]=[CH:8][N:9]=[CH:10][C:11]=4[C:2]3=[N:18]2)[CH:20]=1

참가 물질

4

반응물 2

HCID 109095193-HydrazinopyridineHCID 17608818Ethyl 4-chloro-1,6-naphthyridine-3-carboxylate

생성물 1

HCID 178479606HCID 178479606, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2.84 g of ethyl 4-chloro-1,6-naphthyridine-3-carboxylate and 1.35 g of 3-hydrazinopyridine in 36 ml of methanol is stirred at room temperature for 2.5 hours, then refluxed for 4.5 hours, then cooled in an ice bath and filtered. Collected solid is washed with methanol, then with ether to yield 2-(3-pyridyl)pyrazolo[4,3-c][1,6]naphthyridin-3-(5H)-one hydrochloride, m.p. 302°-305°.

후처리

  1. temperaturerefluxed for 4.5 hours
  2. temperaturecooled in an ice bath
  3. filtrationfiltered
  4. customCollected solid
  5. washis washed with methanol

출처 및 근거

ORD 기록
ord-563f916753134b21b4bc2f43d4041847
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04560689

연결된 노트

불러오는 중…