Ethanol → N-Ethylisonicotinamide

HRID 638305

반응식

HRID 638305 반응식
C(O)C.[CH2:4]([NH2:6])[CH3:5].[C:7](OC)(=[O:14])[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1>O>[CH2:4]([NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)[CH3:5]

참가 물질

5

반응물 3

HCID 702EthanolHCID 6341EthylamineHCID 227085Methyl isonicotinate

생성물 1

HCID 571600N-Ethylisonicotinamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 200 ml of ethanol and 20 ml water was cooled in an ice bath and saturated with ethylamine for 0.5 hr. then 80 g of crude methyl isonicotinate was added with cooling. Ethylamine was again bubbled onto the reaction mixture for 10 min and then it was allowed to stand overnight at room temperature. It was then concentrated in vacuo to leave 82.82 g of a pale oil which became semisolid on cooling.

후처리

  1. temperaturewith cooling
  2. customEthylamine was again bubbled onto the reaction mixture for 10 min
  3. concentrationIt was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-9cbaf1315d844d779728f10b59c9163a
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04560692

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