N-Methyloctadecylamine → 3-(Diphenylphosphanyl)-N-methyl-N-octadecylpropanamide

HRID 638408

반응식

HRID 638408 반응식
C(O[C:4](=[O:20])[CH2:5][CH2:6][P:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)C.[CH3:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40].C[O-].[Na+]>>[CH3:21][N:22]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C:4](=[O:20])[CH2:5][CH2:6][P:7]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

4

반응물 3

HCID 75539N-MethyloctadecylamineHCID 280676Propanoic acid, 3-(diphenylphosphino)-, ethyl esterHCID 10942334Sodium Methoxide

생성물 1

HCID 539331283-(Diphenylphosphanyl)-N-methyl-N-octadecylpropanamide

반응 조건

온도
100 °C

실험 절차

A mixture of 5.7 g ethyl-3-diphenylphosphinopropionate (19.9 mmoles), 5.1 g N-methyl-n-octadecylamine (18.0 mmoles), and 0.3 g sodium methoxide (5.6 mmoles) were first deoxygenated and then heated to 100° C. under a nitrogen atmosphere for 24 hours. The mixture was then cooled and extracted with pentane. The pentane soluble was rotovapped to an oil.

후처리

  1. customwere first deoxygenated
  2. temperatureThe mixture was then cooled
  3. extractionextracted with pentane

출처 및 근거

ORD 기록
ord-fae32b3f8a34410dae043d4e90e56657
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04560806

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