Potassium Carbonate → HCID 53690852, 화합물

HRID 638482

반응식

HRID 638482 반응식
[N+:1]([C:4]1[CH:17]=[C:16]([C:18]([F:21])(F)F)[CH:15]=[CH:14][C:5]=1[O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)([O-:3])=[O:2].Br[CH:23]([CH3:33])[C:24]([O:31][CH3:32])=[CH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[N+:1]([C:4]1[CH:17]=[C:16]([CH2:18][F:21])[CH:15]=[CH:14][C:5]=1[O:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH:23]([CH3:33])[C:24]([O:31][CH3:32])=[CH:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:11][CH:12]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 233251014-[2-Nitro-4-(trifluoromethyl)phenoxy]phenolHCID 53787831Ethyl 4-bromo-3-methoxypent-2-enoate

생성물 1

HCID 53690852HCID 53690852, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-(2-nitro-4-trifluoromethylphenoxy)phenol (9.36 mm), ethyl 4-bromo-3-methoxy-2-pentenoate (12 mm.) and K2CO3 (14 mm.) in acetone (20 ml.) is refluxed for 24 hours. After filtration, the filtrate is concentrated and the oily residue chromatographed on silica gel to yield ethyl 4-[4-(2-nitro-4-fluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoate.

후처리

  1. temperatureis refluxed for 24 hours
  2. filtrationAfter filtration
  3. concentrationthe filtrate is concentrated
  4. customthe oily residue chromatographed on silica gel

출처 및 근거

ORD 기록
ord-38ee8d45f19e47d08476597e77d902e0
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04561882

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