Acetyl chloride → HCID 20252442, 화합물

HRID 638506노트

반응식

HRID 638506 반응식
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:25]=[CH:24][C:13]([O:14][CH:15]([CH3:23])[CH:16]([OH:22])[CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[C:28](Cl)(=[O:30])[CH3:29].C(N(CC)CC)C>C(Cl)Cl>[F:27][C:2]([F:26])([F:1])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:25]=[CH:24][C:13]([O:14][CH:15]([CH3:23])[CH:16]([O:22][C:28](=[O:30])[CH3:29])[CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=2)=[N:7][CH:8]=1

참가 물질

5

반응물 3

HCID 6367Acetyl chloride2회HCID 8471Triethylamine2회HCID 179796Methyl 3-hydroxy-4-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)valerate

생성물 1

HCID 20252442HCID 20252442, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5 g of methyl 4-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]-3-hydroxypentanoate were dissolved in 35 ml of methylene chloride at 0° C. 0.9 ml of acetyl chloride and then 0.94 ml of triethylamine were added dropwise under nitrogen. After 18.5 hours of standing at room temperature and three hours of reflux, an additional 0.9 ml of acetyl chloride and 0.94 ml of triethylamine were added. The mixture was washed with water dilute acid and brine. The product was purified using silica gel chromatography and identified as the above methyl-3-acetoxy ester.

후처리

  1. temperatureof reflux
  2. washThe mixture was washed with water
  3. additiondilute acid and brine
  4. customThe product was purified

출처 및 근거

ORD 기록
ord-64337e2d43dc400eac71e1f089bd78b8
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04561882

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