Formic Acid → 3-Chloro-4-methylbenzaldehyde

HRID 638613노트

반응식

HRID 638613 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[C:5]#N.C(O)=[O:12]>[Al].[Ni]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=[O:12]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 888943-Chloro-p-toluonitrile

생성물 1

HCID 124230853-Chloro-4-methylbenzaldehyde

시약·촉매·용매 1

HCID 6336846Nickel aluminide촉매

실험 절차

A mixture of 3-chloro-4-methylbenzonitrile (4.0 g, 26.39 mmol), formic acid (72 ml, 75% v/v) and nickel aluminum alloy (50/50, 4.8 g) was stirred and heated under reflux for 2 h. The reaction mixture was then filtered hot through Hyflo, and the residue was washed well with hot ethanol. The filtrate was concentrated under reduced pressure to yield a sticky solid. Distillation of this solid afforded 3-chloro-4-methylbenzaldehyde as a colourless oil, b.p. 73°-74°/0.8 mmHg.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 2 h
  3. filtrationThe reaction mixture was then filtered hot through Hyflo
  4. washthe residue was washed well with hot ethanol
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. customto yield a sticky solid
  7. distillationDistillation of this solid

출처 및 근거

ORD 기록
ord-07dc61c1194a4282bc32f8d2ac9f7791
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04562199

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