Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Hydrazide (H3N21-) | HCID 168365 | — |
| 반응물 | 2-Carbamoyl-3-quinolinecarboxylic acid | HCID 1534342 | — |
| 반응물 | Furo[3,4-b]quinoline-1,3-dione | HCID 4325463 | — |
| 생성물 | 2-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid | HCID 13474736 | — |
반응 단계
The aminoamide (24.25 mmol) is added over a two hour period to a solution of 2,3-quinolinedicarboxylic anhydride (20.06 mmol) in pyridine (100 mL) while maintaining the reaction mixture at room temperature. The mixture is allowed to stir at room temperature for one-half hour. Analysis of the isomer distribution of the reaction products by high performance liquid chromatography shows an 8.9/1 ratio of the desired 2-carbamoyl-3-quinolinecarboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04562257 |
| 출처 데이터셋 | uspto-grants-1985_12 |
| ORD ID | ord-526a40f85ffe40aaa4af8111792f6707 |
| 출처 메모 | uspto-grants-1985_12 |