참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 6-(4-Acetylaminophenoxy)-hexanoic acid methyl ester | HCID 49764491 | — |
| 생성물 | 6-(4-Amino-phenoxy)hexanoic acid hydrochloride | HCID 66811347 | 55.6% |
반응 단계
A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07691364B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_04 |
|---|
| ORD ID | ord-aaaf3cd83c2b4643bc5b4bb389e8ae5a |
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| 출처 메모 | uspto-grants-2010_04 |
|---|
