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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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(4-Isocyanato-phenoxy)-acetic acid methyl ester → {4-[2-(4-Methoxycarbonylmethoxy-phenylcarbamoyloxy)-ethoxycarbonylamino]-phenoxy}-acetic acid methyl ester

HRID 638721
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인쇄 미리보기

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HRID 638721 반응식
[CH3:1][O:2][C:3](=[O:19])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([O:15][CH2:16][CH2:17][OH:18])=[O:14])=[CH:8][CH:7]=1.[CH3:20][O:21][C:22](=[O:34])[CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[O:33])=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:19])[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([NH:12][C:13]([O:15][CH2:16][CH2:17][O:18][C:32](=[O:33])[NH:31][C:28]2[CH:27]=[CH:26][C:25]([O:24][CH2:23][C:22]([O:21][CH3:20])=[O:34])=[CH:30][CH:29]=2)=[O:14])=[CH:10][CH:11]=1
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참가 물질

4

반응물 2

HCID 18918618(4-Isocyanato-phenoxy)-acetic acid methyl esterHCID 49764368[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

생성물 1

HCID 59253986{4-[2-(4-Methoxycarbonylmethoxy-phenylcarbamoyloxy)-ethoxycarbonylamino]-phenoxy}-acetic acid methyl ester수율 56.5%

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
50 °C

실험 절차

To [4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester 29 (1 g, 3.72 mmol) in toluene (10 ml) was added (4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (0.8 g, 3.8 mmol) at room temperature and heated to 50° C. for 20 hours. Toluene was distilled off and water (10 ml) was added. Crude 30 was extracted into chloroform, dried over sodium sulphate, distilled and purified by column chromatography on silica gel using chloroform as eluant to get pure 30 (1 g, 56.5%) as a white fluffy powder.

후처리

  1. distillationToluene was distilled off
  2. additionwater (10 ml) was added
  3. extractionCrude 30 was extracted into chloroform
  4. dry with materialdried over sodium sulphate
  5. distillationdistilled
  6. custompurified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-79436a047415479ca8505657f7179884
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07691364B2

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