Benzo(d)thiazol-2-amine → ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylate

HRID 638836노트

반응식

HRID 638836 반응식
Br[CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1>CN(C=O)C>[N:10]1[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:2][N:15]2[C:14]3[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=3[S:12][C:11]=12

참가 물질

4

반응물 2

HCID 8706Benzo(d)thiazol-2-amineHCID 66144Ethyl bromopyruvate

생성물 1

HCID 1480574ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Ethyl bromopyruvate (9.8 g, 50 mmol) was added dropwise to a stirred solution of 2-aminobenzothiazole (7.5 g, 50 mmol) in DMF (100 ml) at room temperature. After the addition, the reaction mixture was heated to reflux for 6 h. The reaction mixture was cooled to room temperature and quenched with ice cold water. The aqueous layer was neutralized with NH4OH and the separated solid was filtered. It was washed well with water and dried. The crude product obtained was taken to next step without purification.

후처리

  1. additionAfter the addition
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux for 6 h
  4. customquenched with ice cold water
  5. filtrationthe separated solid was filtered
  6. washIt was washed well with water
  7. customdried

출처 및 근거

ORD 기록
ord-826f3b8e42574ee88dab8d45fe1c9626
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691842B2

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