Ethyl-7-chloroimidazo(2,1-b)benzothiazole-2-carboxylate → HCID 11218645, 화합물

HRID 638843노트

반응식

HRID 638843 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]3[CH:11]=[C:10]([C:12](OCC)=[O:13])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]3[CH:11]=[C:10]([CH2:12][OH:13])[N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 396584Ethyl-7-chloroimidazo(2,1-b)benzothiazole-2-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 11218645HCID 11218645, 화합물수율 72%

실험 절차

7-chloro imidazo[2,1-b]-benzthiazole-2-methanol was prepared according to the procedure outlined in Example 1, (Step 2). Starting from ethyl 7-chloroimidazo[2,1-b]-benzthiazole-2-carboxylate (9.0 g, 32.1 mmol) and LiAlH4 (4.0 g, excess), 5.5 g (72% yield) of the alcohol derivative was isolated as brown solid. mp 166° C. (M+H) 239.

후처리

  1. custom7-chloro imidazo[2,1-b]-benzthiazole-2-methanol was prepared

출처 및 근거

ORD 기록
ord-9dff3562e835446ab99397b7cc475e68
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691842B2

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