Diethyl (ethoxymethylene)malonate → Diethyl 2-(((6-methoxypyridin-3-yl)amino)methylene)malonate
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.C(O[CH:13]=[C:14]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])C>CCO>[CH2:18]([O:17][C:15](=[O:16])[C:14](=[CH:13][NH:1][C:2]1[CH:7]=[N:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH3:19]참가 물질
4
실험 절차
A solution of 5-amino-2-methoxypyridine (Aldrich, 100 g, 0.806 mole) and diethyl ethoxymethylenemalonate (Aldrich, 163 mL, 0.806 mole) in EtOH (1 L) was heated at reflux for 4 hours, then was cooled to RT. Concentration to dryness gave the title compound (238 g, quantitative).
후처리
- temperatureat reflux for 4 hours
- concentrationConcentration to dryness
출처 및 근거
- ORD 기록
- ord-287e03f9a40440aab29af0260f28c8b6
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691850B2
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