Piperidine → HCID 178467230, 화합물

HRID 639161

반응식

HRID 639161 반응식
[CH3:1][C:2]1[O:6][N:5]=[CH:4][CH:3]=1.C([O-])C.[Na+].[F:11][C:12]([F:26])([F:25])[C:13]1[CH:14]=[C:15]([NH:19][C:20]([CH3:24])=[CH:21][C:22]#[N:23])[CH:16]=[CH:17][CH:18]=1.[CH:27]([C:29]1[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][CH:30]=1)=O.N1CCCCC1>C(O)C>[C:2]([C:3]1[CH:27]([C:29]2[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][CH:30]=2)[C:21]([C:22]#[N:23])=[C:20]([CH3:24])[N:19]([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([C:12]([F:25])([F:26])[F:11])[CH:14]=2)[C:4]=1[NH2:5])(=[O:6])[CH3:1]

참가 물질

7

반응물 5

HCID 8082PiperidineHCID 660424-CyanobenzaldehydeHCID 798335-MethylisoxazoleHCID 2723922Sodium ethoxideHCID 50752873-{[3-(Trifluoromethyl)phenyl]amino}but-2-enenitrile

생성물 1

HCID 178467230HCID 178467230, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Under argon, 100 mg (1.20 mmol) 5-methylisoxazole are dissolved in 2 ml ethanol and 81.90 mg (1.20 mmol) sodium ethanolate are added. The mixture is stirred at room temperature for one hour. Then 272.24 mg (1.20 mmol) of the compound of Example 2A, 157.82 mg (1.20 mmol) 4-formylbenzonitrile and 10.25 mg (11.90 μl, 0.12 mmol) piperidine are added to the mixture which is stirred at reflux overnight. After the reaction is finished, the mixture is purified by preparative HPLC.

후처리

  1. stirringis stirred
  2. temperatureat reflux overnight
  3. customthe mixture is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-5987c91bd2a2434486cda19897fc2df6
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691854B2

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