반응식
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19](=[O:29])[CH2:20][S:21][C:22]3[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][CH:23]=3)[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].Cl.[NH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[C:37]([O:42][CH3:43])[CH:36]=1.C(N(CC)CC)C>>[Br:28][C:25]1[CH:26]=[CH:27][C:22]([S:21][CH2:20][C:19]([N:10]2[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][N:14]3[C:5]([C:3]([NH:33][CH2:34][C:35]4[CH:40]=[CH:39][C:38]([OH:41])=[C:37]([O:42][CH3:43])[CH:36]=4)=[O:4])=[CH:6][CH:7]=[C:8]3[CH2:9]2)=[O:29])=[CH:23][CH:24]=1참가 물질
4
반응물 3
생성물 1
실험 절차
The title compound was synthesized in the manner of Example 81 from 2,2,2-trichloro-1-[10-{[(4-bromophenyl)thio]acetyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-yl]-ethanone of Example 80 and 4-aminomethyl-2-methoxyphenol hydrochloride in the presence of with one equivalent of triethylamine, m.p. 168° C. MS [(+)ESI, m/z]: 592 [M+H]+ Anal. Calcd for C29H26BrN3O4S: C, 58.79; H, 4.42; N, 7.09. Found: C, 58.65; H, 4.46; N, 6.86.
출처 및 근거
- ORD 기록
- ord-553b7f0fc7bb4aa09d1c7d028effafd9
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691848B2
연결된 노트
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