Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Leucinol → 6-Butoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Leucinol | HCID 111307 | — |
| 반응물 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| 반응물 | 6-Butoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68570329 | — |
| 생성물 | 6-Butoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831414 | — |
반응 단계
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-butoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid and (S)-2-amino-4-methyl-pentan-1-ol (commercially available). m/z (ES+): 365.5 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691863B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-82cf2d97b7ad49c48d5a1d8eae38ee2a |
| 출처 메모 | uspto-grants-2010_04 |