Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(+)-L-Leucine methyl ester → (S)-4-Methyl-2-{[5-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carbonyl]-amino}-pentanoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (+)-L-Leucine methyl ester | HCID 65105 | — |
| 반응물 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| 반응물 | 5-Morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid | HCID 68566809 | — |
| 생성물 | (S)-4-Methyl-2-{[5-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carbonyl]-amino}-pentanoic acid methyl ester | HCID 24831738 | — |
반응 단계
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 5-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid and (S)-leucine methyl ester (commercially available). m/z (ES+): 435.3 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691863B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-952a504ad21d4fe9b7e4d8226f00887f |
| 출처 메모 | uspto-grants-2010_04 |