L-Leucinol → 6-(2,2-Dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

반응식

[OH:1][CH2:2][C@@H:3]([NH:8]C(C1C=NC(N2CCCC2)=C(OCCC)N=1)=O)[CH2:4][CH:5]([CH3:7])[CH3:6].[CH3:26][C:27]([CH3:46])([CH3:45])[CH2:28][O:29][C:30]1[N:35]=[C:34]([C:36]([OH:38])=O)[CH:33]=[N:32][C:31]=1[N:39]1[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1.N[C@H](CO)CC(C)C>>[OH:1][CH2:2][C@@H:3]([NH:8][C:36]([C:34]1[CH:33]=[N:32][C:31]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)=[C:30]([O:29][CH2:28][C:27]([CH3:26])([CH3:46])[CH3:45])[N:35]=1)=[O:38])[CH2:4][CH:5]([CH3:7])[CH3:6]

참가 물질

반응물 3

HCID 111307L-Leucinol

HCID 248312586-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

HCID 685693176-(2,2-Dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic-acid

생성물 1

HCID 248317396-(2,2-Dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

실험 절차

In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-(2,2-dimethyl-propoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic-acid and (S)-leucinol (commercially available). m/z (ES+): 395.3 (M+H).