Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-amino-2-ethylbutanoate → 2-Ethyl-2-{[6-(2-methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carbonyl]-amino}-butyric acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-amino-2-ethylbutanoate | HCID 13412527 | — |
| 반응물 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide | HCID 24831258 | — |
| 반응물 | 6-(2-Methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid | HCID 68566649 | — |
| 생성물 | 2-Ethyl-2-{[6-(2-methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carbonyl]-amino}-butyric acid methyl ester | HCID 24831740 | — |
반응 단계
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-(2-methoxy-ethoxy)-5-morpholin-4-yl-pyrazine-2-carboxylic acid and 2-amino-2-ethyl-butyric acid methyl ester (European Journal of Medicinal Chemistry 1984, 19, 261). m/z (ES+): 411.5 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691863B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-50f3d431ee1d41149e1e69e81fbb1c00 |
| 출처 메모 | uspto-grants-2010_04 |