(+)-L-Leucine methyl ester → (S)-2-{[6-Cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester

HRID 639338

반응식

HRID 639338 반응식
OC[C@@H](NC(C1C=NC(N2CCCC2)=C(OCCC)N=1)=O)CC(C)C.[CH:26]1([CH2:31][O:32][C:33]2[N:38]=[C:37]([C:39](O)=[O:40])[CH:36]=[N:35][C:34]=2[N:42]2[CH2:47][CH2:46][C:45]([F:49])([F:48])[CH2:44][CH2:43]2)[CH2:30][CH2:29][CH2:28][CH2:27]1.[CH3:50][O:51][C:52](=[O:59])[C@H:53]([CH2:55][CH:56]([CH3:58])[CH3:57])[NH2:54]>>[CH3:50][O:51][C:52](=[O:59])[C@@H:53]([NH:54][C:39]([C:37]1[CH:36]=[N:35][C:34]([N:42]2[CH2:47][CH2:46][C:45]([F:48])([F:49])[CH2:44][CH2:43]2)=[C:33]([O:32][CH2:31][CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)[N:38]=1)=[O:40])[CH2:55][CH:56]([CH3:58])[CH3:57]

참가 물질

4

반응물 3

HCID 65105(+)-L-Leucine methyl esterHCID 248312586-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amideHCID 685665716-Cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carboxylic acid

생성물 1

HCID 24829470(S)-2-{[6-Cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester

실험 절차

In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 6-cyclopentylmethoxy-5-(4,4-difluoro-piperidin-1-yl)-pyrazine-2-carboxylic acid and (S)-leucine methyl ester (commercially available). m/z (ES+): 469.1 (M+H).

출처 및 근거

ORD 기록
ord-e8626e9125ef487db2730203012e19f5
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691863B2

연결된 노트

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