Tetrahydrofuran → n-(2-(1,3-Dioxolan-2-yl)-4-methoxyphenyl)ethoxycarboxamide

HRID 639353노트

반응식

HRID 639353 반응식
ClC([O:4][CH2:5][CH3:6])=O.[O:7]1[CH2:11][CH2:10][O:9][CH:8]1[C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1N.C([N:23]([CH2:26]C)CC)C.C1C[O:31]CC1>>[O:7]1[CH2:11][CH2:10][O:9][CH:8]1[C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1[CH2:6][CH2:5][O:4][NH:23][CH:26]=[O:31]

참가 물질

5

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 153389082-(1,3-Dioxolan-2-yl)-4-methoxyaniline

생성물 1

HCID 131728036n-(2-(1,3-Dioxolan-2-yl)-4-methoxyphenyl)ethoxycarboxamide

실험 절차

Ethyl chloroformate (1.2 eq) was added to 2-(1,3-dioxolan-2-yl)-4-methoxyphenylamine (1eq) and triethyl amine (1.2 eq) in THF at 0° C. The reaction was completed instantaneously. The mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried and concentrated to give N-(2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)ethoxycarboxamide as a yellow solid in quantitative yield.

후처리

  1. concentrationThe mixture was concentrated
  2. custompartitioned between ethyl acetate and water
  3. washThe organic layer was washed with brine
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-319bb24a285f455989ec0ff3895bfdf0
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691866B2

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