4-Bromoaniline → (4-Bromophenyl)(6-methoxyquinazolin-2-yl)amine

HRID 639355노트

반응식

HRID 639355 반응식
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:12][CH3:13])[CH:8]=2)[N:3]=1.[Br:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>C(O)C>[Br:14][C:15]1[CH:21]=[CH:20][C:18]([NH:19][C:2]2[N:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([O:12][CH3:13])[CH:8]=3)[N:3]=2)=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 78074-BromoanilineHCID 592548522-Chloro-6-methoxyquinazoline

생성물 1

HCID 59254902(4-Bromophenyl)(6-methoxyquinazolin-2-yl)amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-chloro-6-methoxyquinazoline (1eq) and 4-bromoaniline (2 eq) in ethanol was heated at 80° C. for 16 h. The mixture was concentrated and passed through a plug of silica to yield (4-bromophenyl)(6-methoxyquinazolin-2-yl)amine.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-7b1322decbaf43b2835931f1a6221229
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691866B2

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