Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → HCID 68428008, 화합물
반응식
Cl[C:2]1[NH:3][C:4]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:8]=[CH:7][C:5]=2[N:6]=1.[C:17]([O:21][C:22]([N:24]1[CH2:31][C@@H:30]2[C@@H:26]([CH2:27][NH:28][CH2:29]2)[CH2:25]1)=[O:23])([CH3:20])([CH3:19])[CH3:18]>CN1CCCC1=O>[C:17]([O:21][C:22]([N:24]1[CH2:25][C@@H:26]2[C@@H:30]([CH2:29][N:28]([C:2]3[NH:3][C:4]4[CH:10]=[C:9]([C:11]5[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=5)[CH:8]=[CH:7][C:5]=4[N:6]=3)[CH2:27]2)[CH2:31]1)=[O:23])([CH3:20])([CH3:18])[CH3:19]참가 물질
4
반응 조건
- 온도
- 150 °C
실험 절차
2-Chloro-5-phenylbenzimidazole (34 mg) was added to the N-methylpyrrolidone solution (0.2 mL) containing 3-tert-butoxycarbonyl-cis-3,7-diazabicyclo[3.3.0]octane (62 mg), followed by stirring at 150° C. for 4 hrs. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was separated and purified on a silica-gel column chromatograph (C-300, chloroform:THF=4:1) to give the title compound (29 mg).