4-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine → 2-(piperidin-4-yl)-1lambda6,2-thiazolidine-1,1-dione

HRID 639442노트

반응식

HRID 639442 반응식
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][N:10](CC2C=CC=CC=2)[CH2:9][CH2:8]1>[OH-].[Pd+2].[OH-].CO>[O:20]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

참가 물질

4

반응물 1

HCID 462231014-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine

생성물 1

HCID 532560872-(piperidin-4-yl)-1lambda6,2-thiazolidine-1,1-dione

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

20% Palladium hydroxide (100 mg) was added to the methanol solution (5 mL) containing 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-benzylpiperidine (252 mg) at 0° C., followed by stirring at room temperature for 5 hrs. under a hydrogen atmosphere. The reaction mixture was filtered to remove the palladium catalyst, followed by concentration under reduced pressure to give the title compound.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customto remove the palladium catalyst
  3. concentrationfollowed by concentration under reduced pressure

출처 및 근거

ORD 기록
ord-8989cc46dee44dd7a73021652d3582be
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691860B2

반응 노트

불러오는 중…