Sodium Azide → 4-Azidomethyl-1,1-difluorocyclohexane
반응식
[F:1][C:2]1([F:20])[CH2:7][CH2:6][CH:5]([CH2:8]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:4][CH2:3]1.[N-:21]=[N+:22]=[N-:23].[Na+]>CN(C)C=O.ClCCl>[N:21]([CH2:8][CH:5]1[CH2:6][CH2:7][C:2]([F:20])([F:1])[CH2:3][CH2:4]1)=[N+:22]=[N-:23]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
To a solution of toluene-4-sulfonic acid 4,4-difluorocyclohexylmethyl ester (100 mg, 0.33 mmol)) in N,N-Dimethylformamide (0.5 mL) was added sodium azide (32 mg, 0.49 mmol). The reaction mixture was stirred at 90° C. for 90 min, cooled to room temperature and diluted with dichloromethane (5 mL). The organic layer was washed with water (2×5 mL), collected, dried over anhydrous sodium sulfate, filtered, and concentrated to provide the title compound which was used without further purification.
후처리
- temperaturecooled to room temperature
- washThe organic layer was washed with water (2×5 mL)
- customcollected
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-03277e1e80034c9ca1e7975d47e3356a
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691878B2
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