2-Ethyl-1-butanol → Toluene-4-sulfonic acid 2-ethylbutyl ester

HRID 639498노트

반응식

HRID 639498 반응식
[CH2:1]([CH:3]([CH2:6][CH3:7])[CH2:4][OH:5])[CH3:2].C1N2CCN(CC2)C1.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>C(Cl)Cl>[CH2:1]([CH:3]([CH2:6][CH3:7])[CH2:4][O:5][S:22]([C:19]1[CH:20]=[CH:21][C:16]([CH3:26])=[CH:17][CH:18]=1)(=[O:24])=[O:23])[CH3:2]

참가 물질

5

반응물 3

HCID 73582-Ethyl-1-butanolHCID 73974-Toluenesulfonyl chlorideHCID 9237Dabco

생성물 1

HCID 54473552Toluene-4-sulfonic acid 2-ethylbutyl ester수율 95.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 2-ethyl-1-butanol (1.00 g, 9.79 mmol), triethylenediamine (1.32 g, 11.7 mmol) in DCM (30 mL, 0.5 mol) cooled to 0° C. was added p-toluenesulfonyl chloride (1.96 g, 10.3 mmol) in DCM (10 mL) The reaction mixture was stirred for 30 min, and extracted with 1.0N NaOH (2×40 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and isolated by rotary evaporation to give the title compound (2.40 g).

후처리

  1. extractionextracted with 1.0N NaOH (2×40 mL)
  2. customThe organic layer was collected
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customisolated by rotary evaporation

출처 및 근거

ORD 기록
ord-91dd7f8a71bf482bb71f0acd6b525a91
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691878B2

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