(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol → 4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

HRID 639795노트

반응식

HRID 639795 반응식
[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH2:14][OH:15])[CH3:2]>[O-2].[O-2].[Mn+4].ClCCl>[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH:14]=[O:15])[CH3:2]

참가 물질

4

반응물 1

HCID 68431190(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol

생성물 1

HCID 860676734-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

Dichloromethane (4 mL) was added to a vial containing (4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-methanol (56.7 mg, 0.279 mmol) and manganese dioxide (364.3 mg, 4.19 mmol) was added. The vial was sealed and the reaction was allowed to stir for two hours. The reaction was filtered through celite and concentrated to yield the title compound. 1H NMR (CDCl3) δ (ppm): 10.21 (s, 1H), 8.88 (d, 2H), 7.63 (d, 2H), 4.45 (q, 2H), 1.48 (t, 3H).

후처리

  1. additionwas added
  2. customThe vial was sealed
  3. filtrationThe reaction was filtered through celite and
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a3d56a31fdad4b38b1c27b576c108d9a
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691892B2

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