Potassium Hydroxide → HCID 68519611, 화합물
반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([CH3:20])[N:3]=1.[OH-].[K+]>CCO.[Pd]>[Cl-:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[CH:2]=[NH+:3][C:4]([CH3:20])=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
5
실험 절차
1-chloro-6-methoxy-3-methyl-4-phenylisoquinoline (0.55 g) in 25 mL EtOH was treated with 120 mg KOH and 30 mg Pd—C (10%). The reaction was shaken under an H2 atmosphere (50 psi) for 20 h. The reaction was filtered through celite and concentrated to dryness, then dissolved in isopropanol and treated with excess HCl. Crystallization from isopropanol/diethyl ether gave the titled compound.
후처리
- filtrationThe reaction was filtered through celite and
- concentrationconcentrated to dryness
- dissolutiondissolved in isopropanol
- additiontreated with excess HCl
- customCrystallization from isopropanol/diethyl ether
출처 및 근거
- ORD 기록
- ord-77c8c0b27d0944a981e9368c50bdee5f
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691879B2
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