2-Pyridineethanamine → 6-Methoxy-4-phenyl-1-[(2-pyridin-2-ylethyl)amino]isoquinoline-3-carbonitrile

HRID 639909노트

반응식

HRID 639909 반응식
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:7]([C:23]#[N:24])[N:6]=1)[CH:2]=[CH2:3].[N:25]1C=[CH:29][CH:28]=[CH:27][C:26]=1CCN>>[CH3:16][O:15][C:11]1[CH:10]=[C:9]2[C:14](=[CH:13][CH:12]=1)[C:5]([NH:4][CH2:1][CH2:2][C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)=[N:6][C:7]([C:23]#[N:24])=[C:8]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 759192-PyridineethanamineHCID 11358963(Allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile

생성물 1

HCID 114744756-Methoxy-4-phenyl-1-[(2-pyridin-2-ylethyl)amino]isoquinoline-3-carbonitrile

실험 절차

Following the procedure for 1-(allylamino)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using (2-pyridin-2-ylethyl)amine in place of allylamine and heating for 35 min instead of 1 h, the title compound was synthesized.

후처리

  1. temperatureheating for 35 min instead of 1 h

출처 및 근거

ORD 기록
ord-514411d43d9c4ac8b0b288ea929bd328
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691879B2

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