Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Lutidine → N-(cyanomethyl)-2-hydroxy-4-methoxy-N-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Lutidine | HCID 7937 | — |
| 반응물 | Acetonitrile, 2-(methylamino)- | HCID 36652 | — |
| 반응물 | 2-Hydroxy-4-methoxybenzoyl chloride | HCID 23118559 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(cyanomethyl)-2-hydroxy-4-methoxy-N-methylbenzamide | HCID 55207279 | — |
반응 단계
To a solution of 2-hydroxy-4-methoxybenzoyl chloride (22.19 g, 118.9 mmol) in 500 CH2Cl2 were added (methylamino)acetonitrile (10 g, 142.7 mmol) and 2,6-lutidine (19.1 g, 178.4 mmol). The reaction was stirred at rt overnight. The reaction mixture was then partitioned between EtOAc and 1(N) aq HCl. Organic layer washed with 1(N) aq HCl (2×), dried over Na2SO4 and concentrated to light yellow viscous material (24.63 g, 94%). This material was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691879B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-337927e2294b41c7ba3c1c1f19860c77 |
| 출처 메모 | uspto-grants-2010_04 |