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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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ethyl 1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxylate → ethyl 4-amino-1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazole-3-carboxylate

HRID 639975
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인쇄 미리보기

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HRID 639975 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:24])[CH2:10][N:11]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:12]2)[CH:5]=[CH:6][CH:7]=1>[Pd].CO.ClCCl>[NH2:16][C:14]1[C:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:12][N:11]([CH2:10][C:9]([NH:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)=[O:24])[CH:15]=1
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참가 물질

5

반응물 1

HCID 68638240ethyl 1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxylate

생성물 1

HCID 68637919ethyl 4-amino-1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazole-3-carboxylate수율 88.2%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

A mixture of ethyl 1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxylate (0.168 g, 0.5 mmol) was hydrogenated over 10% palladium on carbon (0.034 g) in a mixture of methanol (6 ml) and dichloromethane (3 ml) for 3 hours. The mixture was filtered through Celite and the filtrate was evaporated to leave ethyl 4-amino-1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazole-3-carboxylate (0.135 g, 88% yield):

후처리

  1. filtrationThe mixture was filtered through Celite
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-b346c981c03a43e79240dd573ce6575a
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07691867B2

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