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2-(4-amino-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamide → 2-(4-{[7-(benzyloxy)-6-fluoroquinazolin-4-yl]amino}-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamide hydrochloride

HRID 639988
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인쇄 미리보기

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HRID 639988 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([Cl:19])=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[F:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][C:22]1[CH:23]=[N:24][N:25]([CH2:27][C:28]([NH:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=2)=[O:29])[CH:26]=1>C(O)(C)C.C(OCC)C>[ClH:19].[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([NH:21][C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=4)=[O:29])[CH:26]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[F:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 283740072-(4-amino-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamideHCID 866052297-(Benzyloxy)-4-chloro-6-fluoroquinazoline

생성물 1

HCID 686381152-(4-{[7-(benzyloxy)-6-fluoroquinazolin-4-yl]amino}-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamide hydrochloride수율 95.4%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 3776
Isopropanol
용매

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온도
80 °C

실험 절차

A mixture of 7-(benzyloxy)-4chloro-6-fluoroquinazoline (0.288 g, 1.0 mmol) and 2-(4-amino-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamide (0.234 g, 1.0 mmol) in isopropanol (5 ml) was heated at 80° C. for 10 minutes. The mixture was allowed to cool to room temperature and then diluted with diethyl ether. The resultant solid was filtered to give 2-(4-{[7-(benzyloxy)-6-fluoroquinazolin-4-yl]amino}-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamide hydrochloride (0.499 g, 95% yield) as a yellow solid:

후처리

  1. temperatureto cool to room temperature
  2. filtrationThe resultant solid was filtered

출처 및 근거

ORD 기록
ord-24c3c584a3ca494f8965b881e41c36de
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07691867B2

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