Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Chloropicolinic acid → HCID 58386255, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Chloropicolinic acid | HCID 20812 | — |
| 반응물 | (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine | HCID 58386314 | — |
| 생성물 | HCID 58386255 | HCID 58386255 | 31% |
반응 단계
Prepared by the method as described in Example 68, substituting (R)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine with (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine (Preparation B), and substituting picolinic acid with 6-chloropicolinic acid, to provide the final product as a yellowish solid (9.1 mg, 31% yield). MS (apci) m/z=455.2 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447104B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-84e8f5180b9b495490ef20d39e06e7c5 |
| 출처 메모 | uspto-grants-2016_09 |