3-Hydroxybenzaldehyde → 3-(Cyclopropylmethoxy)benzaldehyde

HRID 640254노트

반응식

HRID 640254 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].[CH:16]1([CH2:19]Cl)[CH2:18][CH2:17]1>CN(C)C=O>[CH:16]1([CH2:19][O:1][C:2]2[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=2)[CH:5]=[O:6])[CH2:18][CH2:17]1

참가 물질

5

반응물 3

HCID 1013-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 80013(Chloromethyl)cyclopropane

생성물 1

HCID 220482703-(Cyclopropylmethoxy)benzaldehyde수율 99.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-Hydroxybenzaldehyde (3 g, 24.6 mmol) and potassium carbonate (10.2 g, 73.8 mmol) were suspended in N,N-dimethylformamide (60 mL). Cyclopropyl methyl chloride (2.86 mL, 29.5 mmol) was added to this suspension, and stirred for 19 hours at room temperature. This mixture was partitioned into ethyl acetate and water. The organic layer was separated, washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (4.32 g).

후처리

  1. customThis mixture was partitioned into ethyl acetate and water
  2. customThe organic layer was separated
  3. washwashed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-f1ef29fe4c7c4f9bbfb873a6700b3963
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691882B2

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