HCID 59255222, 화합물 → HCID 59255438, 화합물
반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][OH:15])[CH:11]=[N:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].C(Cl)Cl>[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[O:15])[CH:11]=[N:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
To a methylene chloride (20 mL) solution of (5-phenoxy-pyridin-3-yl)-methanol (756 mg, 3.76 mmol) described in Manufacturing Example 145-1-2 was added manganese (IV) dioxide (3.27 g, 37.6 mmol), which was stirred for 2 hours at room temperature. The insolubles were removed by filtrating through a Celite pad, after which the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1 to 1:1) to obtain the title compound (607 mg, 81%).
후처리
- customThe insolubles were removed
- filtrationby filtrating through a Celite pad
- concentrationafter which the filtrate was concentrated under a reduced pressure
- customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1 to 1:1)
출처 및 근거
- ORD 기록
- ord-ef2ad916061942a9aafeab37c3e98866
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691882B2
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